Royal Air Force Typhoon FGR4s have operated alongside French aircraft in a combined operation against an underground arms cache in Syria used by the IS group, according to the British defence ministry.
The location, identified by reconnaissance, was thought to be housing weapons and explosive materials, the statement said, and was positioned in hills just north of the ancient city of Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to target a several entry passages down to the site... initial indications are that the objective was successfully hit," officials stated.
There was no indication of any civilian impact in the attack late on Saturday and every plane involved returned to base without incident, the defence officials confirmed.
The Typhoon FGR4s were backed up by a Voyager tanker plane.
The Islamic State group - alternatively referred to as the so-called Islamic State - imposed militant control over parts of both Syria and Iraq prior to its 2019 collapse.
"This action underscores the UK's leading role, and determination to operate in unison with our allies, to stamp out any resurgence of IS and their harmful and extremist ideologies in the Middle East," the British Defence Secretary the Defence Secretary stated.
RAF aircraft have conducted surveillance missions over Syrian airspace to "forestall any attempted resurgence" of IS subsequent to its routing at the Baghuz confrontation in the year 2019, the authorities noted.
"I must thank the personnel of British forces who took part in this operation for their skill and their bravery," the Defence Secretary said. "They were part of thousands of British personnel stationed over the holidays. This mission, to take out dangerous terrorists who endanger our safety, shows how British military are ready to step up, all year round, protecting the UK domestically and influential overseas."
Last December, the American forces conducted what it described as a "major assault" on Islamic State objectives in Syria, following an ambush killed two US troops and a civilian interpreter in the Palmyra area.
The U.N. estimates IS still has between 5,000 and 7,000 militants in Iraq and Syria.